By Zhifei Dai
This ebook highlights the new advances in nanotheranostics from simple learn to strength purposes, and discusses the modular layout and engineering of multiplex nanoparticles together with gold nanostructures, luminescent nanoparticles, dendrimers and liposomes. every one bankruptcy demonstrates multifunctional nanoparticles with issues masking concentrating on, imaging, supply, diagnostics, and remedy as new modalities for melanoma theranostics. This finished e-book offers specialist perspectives at the most up-to-date advancements in theranostic nanomedicine.
It specializes in capability theranostic functions of multifunctional nanoparticles starting from making a choice on noninvasively melanoma cells by means of molecular detection, and visualizing in vivo drug supply via distinction more desirable imaging, to destroying melanoma phone s with minimum unintended effects through selective accumulation at tumor websites, and real-time tracking healing effectiveness. It additionally provides an interdisciplinary survey of nanotheranostics and as such is a important source for researchers and scholars in comparable fields.
Zhifei Dai is a Professor on the division of Biomedical Engineering, collage of Engineering, Peking college, China.
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Additional info for Advances in Nanotheranostics I: Design and Fabrication of Theranosic Nanoparticles
Copyright 2012, American Association for Cancer Research). (g) Polymer-coated AuNCs with capability of releasing chemotherapeutic drugs controllably under NIR light irradiation. (g1) Scheme of polymer-coated AuNCs for drug delivery. (g2) Effects of nanocarriers on cell viability after treatments: (C-1) 2 min irradiation in absence of AuNCs; (C-2) 2 min irradiation in the presence of Dox-free AuNCs; and (2/5 min) 2 min or 5 min irradiation by NIR laser in presence of Dox-loaded AuNCs (Reprinted with permission from ref.
In vivo, efﬁcient NIR ﬂuorescence imaging of tumor sites and improved therapeutic efﬁcacy were 1 Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics 25 obtained by PDT and photothermal dual therapy. Huang et al. developed folic acidconjugated silica-modiﬁed AuNRs for simultaneously targeting, X-ray/CT imaging, radiotherapy, and photothermal therapy . The multifunctional theranostic nanoplatform exhibited excellent imaging and targeting ability for X-ray/CT imaging-guided dual-mode enhanced radio- and photothermal therapy.
Combined thermo-chemotherapy exhibited signiﬁcantly greater cell killing when MDA-MB-231 cells were treated with DOX-loaded HAuNSs plus NIR light . In another work, the thermo-chemotherapy efﬁcacy of DOX-loaded PEG-coated HAuNSs with DOX:PEG:HAuNS weight ratio of 1:3:1 (NP3) was studied in vitro and in vivo using human MDA-MB-231 breast cancer and A2780 ovarian cancer cells . In vitro, signiﬁcantly greater cell killing was observed when cells were treated with both NP3 and NIR light irradiation, which is attributable to the combined photothermal therapy and the released DOX.