Biomarkers of brain injury and neurological disorders by Kevin K. W. Wang, Zhiqun Zhang, Firas H. Kobeissy

By Kevin K. W. Wang, Zhiqun Zhang, Firas H. Kobeissy

''This ebook explores the new advances within the strategies and structures utilized in biomarker examine that experience revolutionized the way in which we learn, diagnose, and deal with mind harm stipulations. The participants describe varied biomarker stories referring to mind damage and different neurological issues and learn different types and applied sciences used to spot those organic markers. The ebook includes Read more...

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Bazarian. 2011. Elevated serum ubiquitin carboxy-terminal hydrolase L1 is associated with abnormal blood–brain barrier function after traumatic brain injury. J Neurotraum. 28: 2453–2462. P. P. S. L. P. T. O. V. A. Stefani. 2011. Neuron-specific enolase, S100B, and glial 30 Biomarkers of Brain Injury and Neurological Disorders fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury. Neurosurgery. 68: 1624. , C. Yao, F. C. May Lu, Z. K. Wang, K. C. R.

Prominent TBI biomarkers in scientific literature Biomarker Location S100B Serum, CSF Neuron Specific Enolase (NSE) Serum, CSF Glial Fibrilllary Acidic Serum, CSF Protein and BDPs Tau Protein Serum, CSF AlphaII-SpectrinSBDP UCH-L1 CSF, Serum CSF, Serum MAP2a/2b Serum Findings Process involved Increased in TBI patients, high Astroglial negative predictive value toward injury/BBB CT findings, yet not specific for TBI damage Increased in serum and CSF of Neuronal Injury TBI patients; low sensitivity and specificity; limited utility due to effect of hemolysis Increased in serum and CSF of Astroglial injury TBI patients; controversy toward specificity as biomarker; CNS specific protein; best if used in combination with NSE and S100B Good outcome prediction in Axonal Injury patients with severe TBI; limited utility in mTBI Possible predictor of outcome in Axonal Injury/ severe TBI; not studied in mild TBI Cell death Useful in assessment of patients Neuronal Injury with severe TBI; better outcome prediction if measured with α-II spectrin; limited studies in mTBI Recently studied; limited evidence; Neuronal Injury reported to increase in the sera of patients with severe TBI Proteomics and Systems Biology in TBI 25 S100B S100B is a low molecular weight calcium-binding protein important in intracellular calcium regulation.

Proteomics tool, namely 2D-DIGE- Proteomics and Systems Biology in TBI 17 MS, was used by Reed et al. (2009) to assess the therapeutic value of GCEE in the treatment of TBI through assessing the effect of GCEE on the protein expression profile difference between rats subject to brain injury with or without GCEE treatment. Results showed that the untreated group showed 19% increase in protein nitration in the brain; however, protein nitration was reduced to below controls with the administration of GCEE.

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