Biomedical Aspects of Histamine: Current Perspectives by Mohammed Shahid, Nancy Khardori, Rahat Ali Khan, Trivendra

By Mohammed Shahid, Nancy Khardori, Rahat Ali Khan, Trivendra Tripathi

Since its id by way of Sir Henry H. Dale a century in the past, histamine has turn into some of the most very important multifunctional biogenic amines within the box of biomedicine. The pharmacological results of histamine are mediated via 4 forms of membrane histamine receptors; H1R, H2R, H3R and H4R, that are all heptahelical G-protein-coupled receptors. it's been identified to play the broadest spectrum of actions in numerous physiological and pathological stipulations together with telephone proliferation, differentiation, hematopoiesis, embryonic improvement, regeneration, wound therapeutic, aminergic neurotransmission and diverse mind capabilities, secretion of pituitary hormones, rules of gastrointestinal and circulatory capabilities, cardiovascular process, in addition to inflammatory reactions, modulation of the immune reaction, endocrine functionality and homeostasis, and different very important components.

This publication is a compendium of the present kingdom of tested and investigational literature on Histamine, its receptors and their Agonists and antagonists. It presents a accomplished evaluate of histamine biology within the box of biochemistry, phone biology, molecular biology, immunology, allergic reaction, neurobiology, pharmacology, microbiology and reproductive biology. the 1st part on Histamine biology and body structure leads into next sections on enzymology, pharmacology, legislation of the immune method and telephone proliferation and position in allergic and different illnesses together with acid peptic illnesses, inflammatory ailments, autoimmune and melanoma ailments, frightened method, reproductive features and hematopoiesis. The compilation of chapters within the booklet offers the latest advances in histamine study and bridges the fundamental and scientific facets of histamine biology.

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1 Introduction Histamine is involved in a wide variety of physiological and pathological responses, such as immediate allergy, inflammation, gastric acid secretion, neurotransmission, and immune modulation (Haas et al. 2008, Jutel et al. 2005, Leurs et al. 2005, Schubert 2007, Thurmond et al.

1. Fig. 2 Synthesis of Histamine Histamine was first identified as an autacoid having potent vasoactive properties. C. C. 26), which is dependent on the cofactor pyridoxal-5 -phosphate to a putative binding site (TFNPSKW) on the protein. Histamine cannot be generated by another enzymatic pathway (Dy 1 Overview of Histamine Synthesis, Regulation and Metabolism 5 and Schneider 2004, Parsons and Ganellin 2006). Histidine decarboxylase (HDC) is an enzyme that is expressed in various cells through out the body, including central nervous system (neurons), gastric-mucosa (parietal cells), mast cells (∼3 pg/cell histamine), and basophils (∼1 pg/cell histamine).

1998). DNA methylation-mediated regulation was also found in the cell type-specific expression of mouse HDC (Suzuki-Ishigaki et al. 2000). Recently, Aichberger et al. demonstrated that the chronic myeloid leukemia (CML)-specific oncoprotein BCR/ABL was involved in induction of histamine synthesis and that H1 receptor antagonists with binding potential to cyp450 can suppress proliferation of human chronic myeloid leukemia cell lines, such as K562 and KU-812 (Aichberger et al. 2006). One of the tissues that exhibit highest HDC activity is fetal liver.

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