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Extra resources for Biomembranes Part R
The only clear common denominator with the substrates is three or four negative charges. Because bongkrekate can penetrate the membranes unspecifically, it is particularly useful in inhibiting transport and is thus ideal for studying the compartmentalization of ADP and ATP within eukaryotic cells. Phloretin and cytochalasin B were also found to bind to the glucose carder from opposite sides of the membrane, phloretin from the outside and cytochalasin B from the insideJ 6,~7 Both remove the substrate and displace each other so that here also ligand binding to only one reorienting substrate site is assumed, and the "singlesite reorientation model" also is extended to the glucose transporter.
4 k Falling with S to Zero, I / k Increasing Linearly with S. (See Fig. ) In this case it is clear that as S increases, each substrate molecule or ion finds itself in an environment in which it becomes increasingly difficult to cross the membrane. Substrate molecules compete with one another for the limited capacity of the transport system, until at limitingly high concentrations, competition is complete and the chances of any particular substrate molecule's being able to find a vacant transporter are zero.
Karlish, W. R. Lieb, D. Ram, and W. D. Stein, Biochim. Biophys. Acta 25S, 126 (1972). ~oL. Lacko, B. Wittke, and H. Kromphardt, Eur. J. Biochem. 25, 447 (1972). 30 TRANSPORT THEORY  obtain these parameters by appropriate curve-fitting procedures? There may also be a nonsaturable permeability 7t, dominant at high substrate concentrations. A transport system may display parameters for zero trans movement in the l-to-2 direction quite different from those in the 2-to-1 direction. Thus, in general, V~t2~ V~t~and K ~ ~ K~tl.