Cartoon Origami 2 by Carlos Gonzalez Santamaria (alias ''Halle'')

By Carlos Gonzalez Santamaria (alias ''Halle'')

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Copyright 2012, American Association for Cancer Research). (g) Polymer-coated AuNCs with capability of releasing chemotherapeutic drugs controllably under NIR light irradiation. (g1) Scheme of polymer-coated AuNCs for drug delivery. (g2) Effects of nanocarriers on cell viability after treatments: (C-1) 2 min irradiation in absence of AuNCs; (C-2) 2 min irradiation in the presence of Dox-free AuNCs; and (2/5 min) 2 min or 5 min irradiation by NIR laser in presence of Dox-loaded AuNCs (Reprinted with permission from ref.

In vivo, efficient NIR fluorescence imaging of tumor sites and improved therapeutic efficacy were 1 Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics 25 obtained by PDT and photothermal dual therapy. Huang et al. developed folic acidconjugated silica-modified AuNRs for simultaneously targeting, X-ray/CT imaging, radiotherapy, and photothermal therapy [73]. The multifunctional theranostic nanoplatform exhibited excellent imaging and targeting ability for X-ray/CT imaging-guided dual-mode enhanced radio- and photothermal therapy.

Combined thermo-chemotherapy exhibited significantly greater cell killing when MDA-MB-231 cells were treated with DOX-loaded HAuNSs plus NIR light [154]. In another work, the thermo-chemotherapy efficacy of DOX-loaded PEG-coated HAuNSs with DOX:PEG:HAuNS weight ratio of 1:3:1 (NP3) was studied in vitro and in vivo using human MDA-MB-231 breast cancer and A2780 ovarian cancer cells [156]. In vitro, significantly greater cell killing was observed when cells were treated with both NP3 and NIR light irradiation, which is attributable to the combined photothermal therapy and the released DOX.

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