By E. Buddecke, H. Kresse, G. Segeth, K. V. Figura (auth.), Professor Dr. Reinhard Fricke, Professor Dr. Fritz Hartmann (eds.)
connective tissues are crucial for the actual functioning of the animals's physique. The situation of some of the connective tissues is ruled via biochemical elements, anabolism and catabolism, which are managed through particular enzymes. Any swap open air the conventional variety of metabolism, for example caused by way of immunological reactions, may perhaps result in a pathological disturbance. the end result could be acute or persistent irritation, or lack of common functionality, expressed in loosening, dilatation, breaking, put on, stiffness, shrinking, scars, stenosis, and cirrhosis or the other type of fibrosis. a primary step towards bettering our realizing of the suggestions mecha nism that keeps the organic prestige and texture of a given connective tissue is to mix what's identified approximately synthesis and enzymatic degradation of the parts of fibers and flooring substance. universal pathological phenomena like persistent irritation of immune reactions might be both the results of the reason for disturbances within the delicate stability of connective tissue metabolism. these days con nective tissues are much less and not more considered as brady trophic tissue yet relatively as a stimulating and many-sided challenge of analysis. prior to we will be able to comprehend the pathogenesis of the connective tissue ailments that bring about the damaging procedures pointed out above, uncomplicated examine could be worthwhile. This learn should be furthered by way of a continuing trade of data and the result of· observations. to advertise this alternate of knowledge among scientists, symposia on connective tissue examine are geared up at typical intervals.
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Additional info for Connective Tissues: Biochemistry and Pathophysiology
Conformation of proteinpolysaccharide complex from bovine nasal septum. J. biol. Chern. 243, 1306 (1968). : Connective tissue proteinpolysaccharides. Fractionation of the proteinpolysaccharides from bovine nasal cartilage. J. biol. Chern. 242, 3460 (1967). : Structure and metabolism of the proteoglycans of dermatan sulfate. A. Balazs: Chemistry and Molecular Biology of the Intercellular Matrix. Vol. 2, p. 823. London: Academic Press 1970. : Ultra centrifugal fractionation of bovine nasal chondromucoproteins.
The concentration of hexosamine in the first extract of acetone-dried corneas was even greater. The hexosamine not extractable with water amounts to 49% in acetone-dried corneas and to 57% in fresh corneas. This observation and the finding of more than 65% of the total hexosamine ifr peptidoglycosaminoglycans of papain digested corneal extracts led to the conclusion that in corneas there will also be proteoglycans not extractable with water, a statement being valid for several other types of connective tissue (Schubert, 1958) .
The specific antigenicity of glutamic acid residues is well known (Sela, 1964): however, that of the linkage region (glcAgal-gal-xyl-ser) is uncertain. Relatively small chondroitin sulfate protein molecules with a short protein core consisting mostly of the amino acids named above could be isolated from pig laryngeal (Muir and Jacobs, 1967) and calf rib cartilage (Kleine, unpublished work) . Antibodies against purified proteochondroitin sulfate absorbed with Ch-4-S peptides do not precipitate this small chondroitin sulfate protein diffusing more rapid in agar gel (Fig.